Objective Measurements of Physical Function to Predict Survival in Patients with Metastatic Cancer. (16th March 2023)

• Record Type: Journal Article
• Authors: Migdanis, Ioannis; Gioulbasanis, Ioannis; Migdanis, Athanasios; Armeni, Eleni; Sgantzos, Markos; Kapsoritakis, Andreas; Kontogianni, Meropi D
• Is Part Of: Nutrition and cancer. Volume 75:Number 3(2023)
• Page Start: 912
• Page End: 922
• Publication Date: 2023-03-16
• Subjects: Cancer -- Periodicals; Nutrition -- Periodicals; Cancer; Nutrition; Periodicals; 616.9940654
• DOI: 10.1080/01635581.2023.2170429
• Languages: English
• ISSNs: 0163-5581

Abstract

Abstract: Background/Objectives: Physician-reported performance status (PS) constitutes the established method for stratifying oncologic patients in therapeutic decision-making. Objective measurements of physical function may further refine prognostication. Subjects/Methods: In this prospective observational study, 103 patients with metastatic cancer who were referred for systemic therapy initiation were evaluated. PS was evaluated using the Eastern Cooperative Oncology Group Performance Status (ECOG-PS) and five objective physical function measurements (handgrip strength [HGS], chair stand test [CST], timed up and go [TUG] test, 4-m gait speed [GS] test, and short physical performance battery [SPPB] test). Overall survival and treatment complications were recorded from the medical records. Results: Patients with low PS according to ECOG-PS (hazard ratio [HR]: 3.80, 95% confidence interval [CI]: 1.84, 7.80), HGS (HR: 2.37, 95% CI: 1.24, 4.55), SPPB (HR: 3.43, 95% CI: 1.55, 7.57), GS (HR: 3.03, 95% CI: 1.44, 6.38), and TUG (HR: 5.16, 95% CI: 2.19, 12.14) had shorter overall survival after adjustment for sex, age, symptomatology, comorbidity, percentage of weight loss, and tumor localization. Conclusions: Among the studied objective physical function measurements, HGS, SPPB, GS, and TUG were independent predictors of survival in a sample of patients with metastatic cancer, with TUG showing the highest effect size.