A novel atropine electrochemical sensor based on silver nano particle-coated Spirulina platensis multicellular blue-green microalga. (May 2023)

• Record Type: Journal Article
• Authors: Ameen, Fuad; Hamidian, Yasamin; Mostafazadeh, Reza; Darabi, Rozhin; Erk, Nevin; Islam, M. Amirul; Orfali, Raha
• Is Part Of: Chemosphere. Volume 324(2023)
• Publication Date: 2023-05
• Subjects: Anticholinergic drug -- Carbon paste electrode -- 1-Hexyl-3 methylimidazolium hexafluorophosphate ion liquid -- Silver electroless -- Atropine sulfate ampoule -- Voltammetry method; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2023.138180
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: In this work, Atropine as the anticholinergic drug was measured using the environmentally friendly sensor. In this regard, Self-cultivated Spirulina platensis with electroless silver was employed as a powder amplifier in carbon paste electrode modification. Also, 1-Hexyl-3 methylimidazolium Hexafluorophosphate (HMIM PF6 ) ion liquid as a conductor binder was used in the suggested electrode construction. Atropine determination was investigated by voltammetry methods. According to voltammograms, the electrochemical behavior of atropine depends on pH, and pH 10.0 was used as the optimal condition. Moreover, the diffusion control process for the electro-oxidation of atropine was verified by the scan rate study, so the diffusion coefficient ( D∼ 3.0136×10 −4 cm 2 /sec ) value was computed from the chronoamperometry study. Furthermore, responses of the fabricated sensor were linear in the concentration range from 0.01 to 800 μM, and the lowest detection limit of the Atropine determination was obtained at 5 nM. Moreover, the stability, reproducibility, and selectivity factors of the suggested sensor were confirmed by the results. Finally, the recovery percentages for atropine sulfate ampoule (94.48–101.58), and water (98.01–101.3) approve of the applicability of the proposed sensor to Atropine determination in real samples. Graphical abstract: Image 1 Highlights: Atropine determination was donevia Spirulina -Ag/HMIM PF6 /CPE. The lowest of detection limit was calculated 5 nM. Analytical ability of amplified electrode was examined in atropine sulfate ampoule and water as real samples. Good recovery range of 94.48–101.58% was achieved for atropine monitoring by Spirulina -Ag/HMIM PF6 /CPE.