Multifunctional two-dimensional Bi2Se3 nanodiscs for anti-inflammatory therapy of inflammatory bowel diseases. (1st April 2023)

• Record Type: Journal Article
• Authors: Zhang, Cong; Li, Qingrong; Shan, Jie; Xing, Jianghao; Liu, Xiaoyan; Ma, Yan; Qian, Haisheng; Chen, Xulin; Wang, Xianwen; Wu, Lian-Ming; Yu, Yue
• Is Part Of: Acta biomaterialia. Volume 160(2023)
• Page Start: 252
• Page End: 264
• Publication Date: 2023-04-01
• Subjects: Inflammatory bowel disease -- Bi2Se3 -- Free radical scavenging -- Reactive oxygen species -- Nanozymes; reactive oxygen species ROS -- inflammatory bowel disease IBD; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1016/j.actbio.2023.02.016
• Languages: English
• ISSNs: 1742-7061

Abstract

Abstract: The overexpression of reactive oxygen and nitrogen species (RONS) in the colonic mucosa destroys the mucosa and its barrier, accelerating the occurrence of inflammatory bowel disease (IBD). The elimination of RONS from the inflammatory colon has proven effective in alleviating IBD. Although many nanoantioxidants have been developed, preparing robust and efficient nano-antioxidants remains challenging. Herein, by modifying bismuth selenide (Bi2 Se3 ) nanodiscs with polyvinylpyrrolidone (PVP), a multifunctional nanozyme based on 2D nanomaterials was developed for the treatment of IBD. By eliminating multiple RONS, such as hydroxyl radicals ( OH), superoxide anions (O2 − ), nitric oxide (NO), and Bi2 Se3 nanodiscs enhanced cellular survival after H2 O2 stimulation. As evidenced by colonic injury, reduced body weight, spleen index, and proinflammatory cytokine levels in mice, RONS clearance alleviated intestinal inflammation in a prevention and delay model of acute colitis. 16S rDNA amplicon sequencing reveals that Bi2 Se3 nanodiscs had the potential to regulate intestinal flora, increase the proportion of Firmicutes to Bacteroidetes, inhibit Proteobacteria bacteria, and restore intestinal homeostasis. This study highlights the use of Bi2 Se3 nanodiscs with excellent biocompatibility, multienzyme functionality, and RONS scavenging ability as treatments for IBD without apparent adverse effects. Statement of Significance: RONS were efficiently scavenged by Bi2 Se3 nanodiscs. Bi2 Se3 nanodiscs could be as a promising and potentially safe theraeputic agent for IBD. The gut microbiota could be modulated by Bi2 Se3 nanodiscs. Graphical abstract: Image, graphical abstract