Similar Results in Liver Transplantation From Controlled Donation After Circulatory Death Donors With Normothermic Regional Perfusion and Donation After Brain Death Donors: A Case‐Matched Single‐Center Study. Issue 12 (7th October 2021)

• Record Type: Journal Article
• Authors: Ruiz, Patricia; Valdivieso, Andres; Palomares, Ibone; Prieto, Mikel; Ventoso, Alberto; Salvador, Patricia; Senosiain, Maria; Fernandez, Jose Ramon; Testillano, Milagros; Bustamante, Francisco Javier; Gastaca, Mikel
• Is Part Of: Liver transplantation. Volume 27:Issue 12(2021)
• Page Start: 1747
• Page End: 1757
• Publication Date: 2021-10-07
• Subjects: Liver -- Transplantation -- Periodicals; Liver -- Diseases -- Periodicals; Liver Transplantation -- Periodicals; Foie -- Greffe -- Périodiques; 617.5560592
• DOI: 10.1002/lt.26281
• Languages: English
• ISSNs: 1527-6465

Abstract

Abstract : Although good results have been reported with the use of normothermic regional perfusion (NRP) in controlled donation after circulatory death (cDCD) liver transplantation (LT), there is a lack of evidence to demonstrate similar results to donation after brain death (DBD). We present a single‐center retrospective case‐matched (1:2) study including 100 NRP cDCD LTs and 200 DBD LTs and a median follow‐up of 36 months. Matching was done according to donor age, recipient Model for End‐Stage Liver Disease score, and cold ischemia time. The following perioperative results were similar in both groups: alanine transaminase peaks of 909 U/L in the DBD group and 836 U/L in the cDCD group and early allograft disfunction percentages of 21% and 19.2%, respectively. The 1‐year and 3‐year overall graft survival for cDCD was 99% and 93%, respectively, versus 92% and 87%, respectively, for DBD ( P = 0.04). Of note, no cases of primary nonfunction or ischemic‐type biliary lesion were observed among the cDCD grafts. Our results confirm that NRP cDCD LT meets the same outcomes as those obtained with DBD LT and provides evidence to support the idea that cDCD donors per se should no longer be considered as "marginal donors" when recovered with NRP.