Heterozygosity of the Alpha 1‐Antitrypsin Pi*Z Allele and Risk of Liver Disease. Issue 8 (3rd April 2021)

• Record Type: Journal Article
• Authors: Hakim, Aaron; Moll, Matthew; Qiao, Dandi; Liu, Jiangyuan; Lasky‐Su, Jessica A.; Silverman, Edwin K.; Vilarinho, Silvia; Jiang, Z. Gordon; Hobbs, Brian D.; Cho, Michael H.
• Is Part Of: Hepatology communications. Volume 5:Issue 8(2021)
• Page Start: 1348
• Page End: 1361
• Publication Date: 2021-04-03
• Subjects: Hepatology -- Periodicals; Liver -- Diseases -- Periodicals; Liver Diseases; Gastroenterology; Periodicals; Fulltext; Internet Resources; Periodicals; 616.36
• DOI: 10.1002/hep4.1718
• Languages: English
• ISSNs: 2471-254X

Abstract

Abstract : The serpin family A member 1 ( SERPINA1 ) Z allele is present in approximately one in 25 individuals of European ancestry. Z allele homozygosity (Pi*ZZ) is the most common cause of alpha 1‐antitrypsin deficiency and is a proven risk factor for cirrhosis. We examined whether heterozygous Z allele (Pi*Z) carriers in United Kingdom (UK) Biobank, a population‐based cohort, are at increased risk of liver disease. We replicated findings in Massachusetts General Brigham Biobank, a hospital‐based cohort. We also examined variants associated with liver disease and assessed for gene–gene and gene–environment interactions. In UK Biobank, we identified 1, 493 cases of cirrhosis, 12, 603 Z allele heterozygotes, and 129 Z allele homozygotes among 312, 671 unrelated white British participants. Heterozygous carriage of the Z allele was associated with cirrhosis compared to noncarriage (odds ratio [OR], 1.53; P = 1.1×10 −04 ); homozygosity of the Z allele also increased the risk of cirrhosis (OR, 11.8; P = 1.8 × 10 −09 ). The OR for cirrhosis of the Z allele was comparable to that of well‐established genetic variants, including patatin‐like phospholipase domain containing 3 ( PNPLA3 ) I148M (OR, 1.48; P = 1.1 × 10 −22 ) and transmembrane 6 superfamily member 2 ( TM6SF2 ) E167K (OR, 1.34; P = 2.6 × 10 −06 ). In heterozygotes compared to noncarriers, the Z allele was associated with higher alanine aminotransferase (ALT; P = = 4.6 × 10 −46 ), aspartate aminotransferase (AST; P = 2.2 × 10 −27 ), alkaline phosphatase ( P = 3.3 × 10 −43 ), gamma‐glutamyltransferase ( P = 1.2 × 10 −05 ), and total bilirubin ( P = 6.4 × 10 −06 ); Z allele homozygotes had even greater elevations in liver biochemistries. Body mass index (BMI) amplified the association of the Z allele for ALT ( P interaction = 0.021) and AST ( P interaction = 0.0040), suggesting a gene–environment interaction. Finally, we demonstrated genetic interactions between variants in PNPLA3, TM6SF2, and hydroxysteroid 17‐beta dehydrogenase 13 ( HSD17B13 ); there was no evidence of epistasis between the Z allele and these variants. Conclusion: SERPINA1 Z allele heterozygosity is an important risk factor for liver disease; this risk is amplified by increasing BMI. Abstract : image