Genome Sequencing and Apoptotic Markers to Assess Treatment Response of Lacrimal Gland Adenoid Cystic Carcinoma to Intra-Arterial Cytoreductive Chemotherapy. Issue 2 (March 2022)

• Record Type: Journal Article
• Authors: Yu, Michael D.; Men, Clara J.; Do, Huy; Colevas, A. Dimitrios; Lin, Jonathan H.; Egbert, Peter R.; Tse, David T.; Kossler, Andrea L.
• Is Part Of: Ophthalmic plastic and reconstructive surgery. Volume 38:Issue 2(2022)
• Publication Date: 2022-03
• Subjects: Eye -- Surgery -- Periodicals; Ophthalmic plastic surgery -- Periodicals; Reconstructive Surgical Procedures -- Periodicals; Ophthalmologic Surgical Procedures -- Periodicals; Ophthalmology -- Periodicals; Surgery -- Periodicals; 617.70592
• DOI: 10.1097/IOP.0000000000002079
• Languages: English
• ISSNs: 0740-9303

Abstract

Abstract : Adenoid cystic carcinoma of the lacrimal gland is an aggressive, malignant epithelial neoplasm. We report the case of a 30-year-old male with lacrimal gland adenoid cystic carcinoma treated with neoadjuvant intra-arterial chemotherapy through the internal carotid artery, followed by orbital exenteration and chemoradiation. Treatment response was evaluated using a novel combination of pre- and posttreatment genome sequencing coupled with immunohistochemical evaluation, which showed diffuse tumor apoptosis. A posttreatment decrease in variant allele frequency of the NOTCH1 mutation, and robust tumor cytoreduction on imaging, supports exploration of NOTCH1 analysis as a potential marker of cisplatin sensitivity. The use of genome sequencing and immunohistochemical evaluation could provide a more targeted therapeutic assessment of neoadjuvant intra-arterial chemotherapy in the management of lacrimal gland adenoid cystic carcinoma. Abstract : A 30-year-old male with lacrimal gland adenoid cystic carcinoma was treated with intra-arterial chemotherapy through the internal carotid artery. Treatment response was evaluated using pre- and post-treatment genome sequencing and immunohistochemical analysis with tumor apoptosis markers.