Large Anterior Mediastinal Mass and Cardiac Infiltration at Diagnosis in a Child With T-cell Acute Lymphoblastic Leukemia. Issue 2 (March 2022)

• Record Type: Journal Article
• Authors: Meyer, Erin J.; Umaretiya, Puja; Vrooman, Lynda M.
• Is Part Of: Journal of pediatric hematology/oncology. Volume 44:Issue 2(2022)
• Publication Date: 2022-03
• Subjects: T-call acute lymphoblastic leukemia -- cardiac mass -- interventricular septum; Pediatric hematology -- Periodicals; Tumors in children -- Periodicals; 618.9215
• DOI: 10.1097/MPH.0000000000002360
• Languages: English
• ISSNs: 1077-4114

Abstract

Abstract : While anterior mediastinal masses are a common presenting feature of T-cell acute lymphoblastic leukemia, cardiac leukemic infiltration is an exceedingly rare extramedullary manifestation. We report a 4-year-old female with new-onset T-cell acute lymphoblastic leukemia who was found to have a large interventricular septal mass upon initial presentation. This patient required a unique management approach with serial echocardiograms, continuous telemetry, and hemodynamic monitoring with close surveillance for ventricular ectopy. Given a good response to traditional leukemia therapy, the cardiac mass was presumed to have been a focal infiltrate of leukemic cells.