Exacerbation of Ulcerative Colitis following Administration of 5-ASA Enemas. (1st April 1989)

• Record Type: Journal Article
• Authors: Young, Barbara A.; McLeod, Robin S.; Cohen, Zane
• Is Part Of: Canadian Journal of Gastroenterology. Volume 3:Number 2(1989)
• Page Start: 50
• Page End: 52
• Publication Date: 1989-04-01
• Subjects: 5-Aminosalicylic acid (5-ASA) -- Drug induced colitis
• DOI: 10.1155/1989/461926
• Languages: English
• ISSNs: 0835-7900

Abstract

Abstract : A 33-year-old female with a 15 year history of ulcerative colitis presented with worsening diarrhea following colectomy and ileorectal anastomosis six months previously. Following administration of 5-ASA enemas (Salofalk). the patient developed abdominal cramps. nausea and vomiting. and severe diarrhea resulting in hypotension. Symptoms abated quickly when the 5-ASA enemas, were discontinued. Although diarrhea and abdominal cramps have been described previously as side effects of oral sulfasalazine. oral 5-ASA and sulfasalazine enemas, this is the first report of these symptoms occurring following administration of 5-ASA enemas.