Topical Treatment of Ulcerative Colitis using Enemas Containing 5-Aminosalicylic Acid and Beclomethasone Dipropionate. (1st November 1990)

• Record Type: Journal Article
• Authors: Campieri, M; Gionchetti, P; Belluzzi, A; Tampieri, M; Brignola, C; Ferretti, M; Miglioli, M; Barbara, L
• Is Part Of: Canadian Journal of Gastroenterology. Volume 4:Number 7(1990)
• Page Start: 481
• Page End: 483
• Publication Date: 1990-11-01
• Subjects: Beclomethasone -- Clinical trial -- Enemas -- Topical therapy -- Ulcerative colitis
• DOI: 10.1155/1990/164896
• Languages: English
• ISSNs: 0835-7900

Abstract

Abstract : 5-Aminosalicylic acid (5-ASA) enemas constitute a first-line therapy for patients with mild to moderate attacks of ulcerative colitis. To date, based on the results of different studies, 5-ASA enemas appear to be satisfactory in at least two-thirds of patients treated. Beclomethasone is one of the new corticosteroids which appear to have minimal systemic effects. The authors have assessed the efficacy of a four week course of 3 mg beclomethasone enemas compared to 2 g 5-ASA enemas in patients with ulcerative colitis. Preliminary analysis would suggest that both therapies are effective in more than 50% of cases.