5-ASA Suppositories in Hemorrhoidal Disease. (1st February 1992)

• Record Type: Journal Article
• Authors: Gionchetti, P; Campieri, M; Belluzzi, A; Brignola, C; Miglioli, M; Barbara, L
• Is Part Of: Canadian Journal of Gastroenterology. Volume 6:Number 1(1992)
• Page Start: 18
• Page End: 20
• Publication Date: 1992-02-01
• Subjects: Hemorrhoidal disease -- Mesalazine suppositories
• DOI: 10.1155/1992/715270
• Languages: English
• ISSNs: 0835-7900

Abstract

Abstract : Forty patients with active hemorrhoidal disease were entered into this double-blind trial, 20 of whom were randomized to treatment with 5-aminosalicylic acid (5-ASA) (500 mg) suppositories. Clinical and sigmoidoscopic assessment was carried out before the start of the trial and after two weeks of treatment. At the end of the study, 5-ASA suppositories showed results superior to those of placebo for all parameters evaluated (P<0.01). There were no adverse events reported related to the use of suppositories. 5-ASA suppositories are a valid therapeutic approach for hemorrhoidal disease as it reduces the intensity of all symptoms and significantly decreases congestion of the hemorrhoidal plexus.