099 Increased Risk of Subsequent Cardiovascular Disease Among Men Aged 31-60 Years with Erectile Dysfunction. (1st May 2022)

• Record Type: Journal Article
• Authors: Huang, I; Chen, W; Huang, EY; Chung, H; Huang, WJ
• Is Part Of: Journal of sexual medicine. Volume 19(2022)Supplement 2
• Page Start: S163
• Page End: S163
• Publication Date: 2022-05-01
• Subjects: Sexual disorders -- Periodicals; Sex -- Periodicals; Sexual health -- Periodicals; 616.69005
• DOI: 10.1016/j.jsxm.2022.03.373
• Languages: English
• ISSNs: 1743-6095

Abstract

ABSTRACT: Background: Men presenting with erectile dysfunction (ED) or coronary artery disease (CAD) can be regarded as two different manifestation of vascular occlusion incident. ED has been proven to be an independent predictor of CAD, especially young men aged 40-49 years. Although psychogenic ED is more prevalent in younger patients less than 40 years of age, but the ED presentation can also be related to vasculogenic etiology. The purpose of this study is to evaluate the subsequent CAD risk in young ED patients and also determine the relative CAD risk in ED men stratified by age. Methods: A total of 3091 ED patients and 9273 randomly-selected controls without ED were selected from the National research database and studied retrospectively from January 1, 1997 to December 31, 2007. The comparison cohort without ED was matched for age and comorbidities (diabetes, hypertension, hyperlipidemia and ischemic stroke). All subjects were followed up by the end of 2009. Cox proportional hazards regression models were used to explore the connection between ED and the development of CAD. Results: The ED patients have a greater chance of developing cardiovascular disease compared to controls (460/3091, 14.9% vs. 1021/9273, 11.0%, p -values < 0.0001). Cox proportional hazards regression suggested ED increases the risk of CAD development (HR 1.37, 95% CI [1.22-1.53], p<0.0001). Results stratified by 10-year age decades demonstrate ED men aged 31-40 years, 41-50 years, and 51-60 years pose greater risk of developing CAD comparing to the controls (HR 1.61, 95% CI [1.04-2.52], p =0.03; HR 1.79, 95% CI [1.38-2.32], p < 0.0001; HR 1.68, 95% CI [1.35-2.09], p < 0.0001, respectively). On the contrary, the incident cardiac events were not increased in ED men aged 21-30 years, 61-70 years and 71-80 years comparing to the controls (HR 1.77, 95% CI [0.50-6.29], p =0.38; HR 1.17, 95% CI [0.95-1.44], p =0.15; HR 0.88, 95% CI [0.65-1.19], p =0.40, respectively). Conclusion: Erectile dysfunction is a harbinger of cardiovascular clinical events in men aged 31-60 years. Erectile dysfunction should prompt investigation and close follow up for further cardiac events. Disclosure: Work supported by industry: no.