Ciprofloxacin or Imipenem Use Correlates with Resistance in Pseudomonas aeruginosa. (1998)

• Record Type: Journal Article
• Authors: Zhanel, George G; Nicolle, Lindsay E; Gin, Alfred S; Karlowsky, James; Kabani, Amin; Hoban, Daryl J
• Is Part Of: Canadian Journal of Infectious Diseases. Volume 9:Number 6(1998)
• Page Start: 382
• Page End: 386
• Publication Date: 1998
• Subjects: Ciprofloxacin -- Imipenem -- Resistance -- Pseudomonas aeruginosa
• DOI: 10.1155/1998/210742
• Languages: English
• ISSNs: 1180-2332

Abstract

Abstract : OBJECTIVE: To investigate the relationship between ciprofloxacin or imipenem use and antimicrobial resistance in Pseudomonas aeruginosa . METHODS: A retrospective review of monthly antimicrobial susceptibility reports for ciprofloxacin (1988 to 1995) and imipenem (1987 to 1995) against P aeruginosa and hospital antimicrobial use records at a tertiary care teaching hospital in Winnipeg, Manitoba. Data were entered into a relational database, R:Base 4.5++, collated, transferred to a spreadsheet and subjected to linear regression analysis. The relationship between ciprofloxacin or imipenem use and resistance was assessed using a Pearson correlation. RESULTS: Ciprofloxacin-resistant P aeruginosa increased from 1.0% of all isolates in 1988 to 10.0% in 1995. A significant (P=0.05) correlation was demonstrated between the amount of ciprofloxacin use and prevalence of ciprofloxacin-resistant P aeruginosa (r=0.73, P=0.05). Imipenem-resistant P aeruginosa increased from 1.0% of isolates in 1987 to a maximum of 10.4% in 1991, and subsequently decreased to 5.4% in 1995. Imipenem use and the prevalence of imipenem-resistant P aeruginosa were significantly correlated (r=0.85, P=0.014). CONCLUSIONS: Ciprofloxacin use was directly associated with ciprofloxacin resistance, and imipenem use was directly associated with imipenem resistance in P aeruginosa .