NipahVR: a resource of multi-targeted putative therapeutics and epitopes for the Nipah virus. (24th February 2020)

• Record Type: Journal Article
• Authors: Gupta, Amit Kumar; Kumar, Archit; Rajput, Akanksha; Kaur, Karambir; Dar, Showkat Ahmed; Thakur, Anamika; Megha, Kirti; Kumar, Manoj
• Is Part Of: Database. Volume 2020(2020)
• Publication Date: 2020-02-24
• Subjects: Nipah virus -- Therapeutics -- Vaccine epitope -- diagnostics -- siRNAs -- miRNAs -- sgRNAs; Biology -- Databases -- Periodicals; Bioinformatics -- Periodicals; 570.285
• DOI: 10.1093/database/baz159
• Languages: English
• ISSNs: 1758-0463

Abstract

Abstract: Nipah virus (NiV) is an emerging and priority pathogen from the Paramyxoviridae family with a high fatality rate. It causes various diseases such as respiratory ailments and encephalitis and poses a great threat to humans and livestock. Despite various efforts, there is no approved antiviral treatment available. Therefore, to expedite and assist the research, we have developed an integrative resource NipahVR (http://bioinfo.imtech.res.in/manojk/nipahvr/ ) for the multi-targeted putative therapeutics and epitopes for NiV. It is structured into different sections, i.e. genomes, codon usage, phylogenomics, molecular diagnostic primers, therapeutics (siRNAs, sgRNAs, miRNAs) and vaccine epitopes (B-cell, CTL, MHC-I and -II binders). Most decisively, potentially efficient therapeutic regimens targeting different NiV proteins and genes were anticipated and projected. We hope this computational resource would be helpful in developing combating strategies against this deadly pathogen. Database URL: http://bioinfo.imtech.res.in/manojk/nipahvr/