Positive Correlation between Normal Serum Gastrin Concentrations and Antral and Duodenal G Cells. (1st August 1994)

• Record Type: Journal Article
• Authors: Yacoub, WR; Thomson, ABR; Sherbaniuk, RW; Hooper, P; Jewell, LD
• Is Part Of: Canadian Journal of Gastroenterology. Volume 8:Number 4(1994)
• Page Start: 235
• Page End: 238
• Publication Date: 1994-08-01
• Subjects: Gastric endocrine cells -- Gastrin -- Immunohistochemistry -- Morphometry
• DOI: 10.1155/1994/151096
• Languages: English
• ISSNs: 0835-7900

Abstract

Abstract : It is controversial whether there is a correlation between serum gastrin concentrations and the density of G cells in the antral or duodenal mucosa. In this study, endoscopically obtained antral and duodenal biopsies were stained immunocytochemically for gastrin and the G cells quantitated using an MOP Videoplan computer image analysis system. Studies were performed in 20 patients with acid-peptic disorders (gastric ulcer, n=5; duodenal ulcer, n=10; reflux esophagitis, n=4; and nonulcer dyspepsia, n=1). Correlations between antral and duodenal G cell densities, and basal- and food-stimulated serum gastrin concentrations within the normal range (less than 100 mg/L) – but not in those with elevated gastrin concentrations – support the postulate that alterations in G cell function are important in patients with acid-peptic disorders.