Platelet-release reaction in myocardial infarction. Issue 6207 (12th January 1980)

• Record Type: Journal Article
• Authors: Heptinstall, S; Mulley, G P; Taylor, P M; Mitchell, J R
• Is Part Of: BMJ. Volume 280:Issue 6207(1980)
• Page Start: 80
• Page End: 81
• Publication Date: 1980-01-12
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.280.6207.80
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : A study was made of the platelet-release reaction in heparinised platelet-rich plasma taken from 26 patients, of whom 22 had sustained a definite and four a possible myocardial infarction, and from 54 age-matched controls. No significant differences in reaction were observed between the two groups. Signficant differences were seen, however, between eight patients who died within a year after infarction and the controls (P less than 0.01) and the remaining 18 patients who survived (P = 0.02). These differences were abolished when sodium citrate was included in the experimental procedure. Poor prognosis was thus related to an increased platelet-release reaction after infarction.