3D nanofiber sponge with dimethyloxaloglycine-loaded Prussian blue analogue microspheres to promote wound healing. (1st May 2023)

• Record Type: Journal Article
• Authors: Chen, Jiatian; Huang, Zihang; Wu, Xiaotong; Xia, Dan; Chen, Ziyu; Wang, Donghui; Liang, Chunyong; Li, Jinhua
• Is Part Of: Biomedical materials. Volume 18:Number 3(2023)
• Publication Date: 2023-05-01
• Subjects: 3D nanofiber sponge -- Prussian blue analogues -- dimethyloxaloglycine -- wound healing; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1088/1748-605X/acc99b
• Languages: English
• ISSNs: 1748-6041

Abstract

Abstract: The fabrication of functional wound dressing for effective hemostasis, anti-inflammation as well as angiogenesis is of vital importance. In this paper, a three-dimensional (3D) nanofiber sponge with dimethyloxaloglycine (DMOG) loaded mesoporous spheres of derivatives of Prussian blue analogues (PBAs) was prepared (3D-PBAFeCo -DMOG). The nanostructure, composition, and mechanical properties of 3D-PBAFeCo -DMOG were characterized, showing regular nanostructure and good mechanical property. The behavior of in vitro drug release showed the DMOG could achieve long-term and stable release by encapsulating in PBAFeCo microspheres and nanofibers. In vitro coagulation experiments showed that 3D-PBAFeCo -DMOG had effective hemostasis and clotting capacities. In addition, the antioxidant capacity and cell compatibility of 3D-PBAFeCo -DMOG were confirmed. These results indicate that 3D-PBAFeCo -DMOG nanofiber sponge, as a controlled drug release system, may provide a new strategy for promoting angiogenesis and wound healing for clinical applications.