Evidence that type I diabetes and thyrogastric autoimmunity have different genetic determinants. Issue 6208 (19th January 1980)

• Record Type: Journal Article
• Authors: Gorsuch, A N; Dean, B M; Bottazzo, G F; Lister, J; Cudworth, A G
• Is Part Of: BMJ. Volume 280:Issue 6208(1980)
• Page Start: 145
• Page End: 147
• Publication Date: 1980-01-19
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.280.6208.145
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : The prevalences of autoimmune endocrine disease and relevant organ-specific autoantibodies were determined in 141 patients with type I (insulin-dependent) diabetes and their families. All available members of the families were genotyped for HLA. Islet-cell antibody was found in 10 (4%) out of 248 unaffected siblings, all of whom were genetically potential cases of diabetes. One developed classical symptoms six months later. In contrast, thyroid and gastric parietal-cell antibodies occurred independent of the HLA-linked susceptibility to diabetes. These results suggest that different genes control the production of these autoantibodies and the susceptibility to type I diabetes.