Verrucous epidermal nevus as a manifestation of a type 2 mosaic PTEN mutation in Cowden syndrome. Issue 1 (24th September 2022)

• Record Type: Journal Article
• Authors: Plana‐Pla, Adrià; Condal, Laura; Jaka, Ane; Blanco, Ignacio; Castellanos, Elisabeth; Bielsa, Isabel
• Is Part Of: Pediatric dermatology. Volume 40:Issue 1(2023)
• Page Start: 179
• Page End: 181
• Publication Date: 2022-09-24
• Subjects: Cowden syndrome -- epidermal nevus -- lipoma -- macrocephaly -- mosaicism type 2 -- PTEN; Pediatric dermatology -- Periodicals; Children -- Diseases -- Periodicals; 618.925
• DOI: 10.1111/pde.15116
• Languages: English
• ISSNs: 0736-8046

Abstract

Abstract: Linear Cowden nevus, also known as linear PTEN nevus, is a type of epidermal nevus, first described in 2007, which is seen in patients with PTEN hamartoma tumor syndrome. It is considered to be a type 2 form of segmental mosaicism, and we suggest that it has certain clinical features that distinguish it from epidermal nevi seen in similar conditions, such as Proteus syndrome. We present a case of linear Cowden nevus in a 4‐year‐old boy and review the literature.