Calciphylaxis and its co‐occurrence with connective tissue diseases. Issue 4 (23rd October 2022)

• Record Type: Journal Article
• Authors: Zhou, Yueyuan; Chen, Yuehong; Yin, Geng; Xie, Qibing
• Is Part Of: International wound journal. Volume 20:Issue 4(2023)
• Page Start: 1316
• Page End: 1327
• Publication Date: 2022-10-23
• Subjects: arterial calcification -- calciphylaxis -- connective tissue diseases -- giant cell arteritis -- systemic lupus erythematosus; Wounds and injuries -- Treatment -- Periodicals; Wounds and injuries -- Periodicals; Wound healing -- Periodicals; 617.1005
• DOI: 10.1111/iwj.13972
• Languages: English
• ISSNs: 1742-4801

Abstract

Abstract: Calciphylaxis, also known as calcific uremic arteriopathy, is a rare calcification syndrome that presents as ischemic skin necrosis and severe pain. It has a high mortality rate and is characterised by calcification of the small and medium arteries and micro‐thrombosis. Calciphylaxis mainly occurs in patients with end‐stage renal disease. In recent years, there have been an increasing number of cases of calciphylaxis associated with connective tissue diseases. Given the absence of clear diagnostic criteria for calciphylaxis thus far, an early diagnosis is crucial for designing an effective multidisciplinary treatment plan. In this article, we review the research progress on calciphylaxis and describe its characteristics in the context of connective tissue diseases.