Multicomponent Selective Thioetherification of KSAc: Easy Access to Symmetrical/Unsymmetrical 4‐Alkylthio‐3‐halo‐2(5H)‐furanones. Issue 3 (24th February 2023)

• Record Type: Journal Article
• Authors: Zhou, Yong‐Jun; Fang, Yong‐Gan; Yang, Kai; Yu, Shi‐Wei; Chen, Zu‐Jia; Wang, Bi‐Cheng; Zhan, Hai‐Ying; Wang, Zhao‐Yang
• Is Part Of: Asian journal of organic chemistry. Volume 12:Issue 3(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-02-24
• Subjects: C−S bond formation -- 2(5H)-furanones -- Potassium thioacetate -- Symmetrical/unsymmetrical synthesis -- Transition-metal-free; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.202300038
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract: An easy two‐/three‐component selective thioetherification of KSAc for the synthesis of a series of symmetrical/unsymmetrical 4‐alkylthio‐3‐halo‐2(5 H )‐furanones has been described. The reaction without any metal catalyst or additive is carried out in air atmosphere at room temperature for 5 h, only using potassium thioacetate as an odourless sulfur source and a base simultaneously. The broad substrate scope and high yield make it important for the studies on both constructing C−S bond based on non‐aryl Csp2 −X bond and synthesizing new 2(5 H )‐furanone functional molecules. Abstract : A transition metal‐free catalyzed synthesis of symmetrical/unsymmetrical 4‐alkylthio‐3‐halo‐2(5 H )‐furanones has been developed. The reaction without any metal catalyst or additive is carried out in air atmosphere at room temperature for 5 h only using potassium thioacetate as an odorless sulfur source and a base simultaneously.