68Ga-DOTA-FAPI-04 PET/CT Imaging in a Case of SAPHO Syndrome. (March 2022)

• Record Type: Journal Article
• Authors: Xu, Tingting; Huang, Yilin; Zhao, Yan; Wang, Peng; Chen, Yue
• Is Part Of: Clinical nuclear medicine. Volume 47:Number 3(2022)
• Publication Date: 2022-03
• Subjects: 68Ga-DOTA-FAPI-04 -- SAPHO syndrome -- synovitis -- PET/CT; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000003901
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: A 66-year-old woman presented with anterior chest wall and knee joints pain and multiple skin lesions. 99m Tc-MDP bone scintigraphy showed increased bone density in the sternal angle with abnormal bone metabolism. The patient was enrolled in a 68 Ga-DOTA-FAPI-04 PET/CT tumor clinical trial, and it showed increased tracer uptake in the sternum and right knee joint. Subsequently, ultrasound of the right knee joint confirmed the existence of synovitis, and no malignant components were found in sternal biopsy. The patient's final diagnosis was synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. The case confirmed that 68 Ga-DOTA-FAPI-04 imaging is helpful for evaluating the involved sites of SAPHO syndrome.