Myocardial injury: where inflammation and autophagy meet. Issue 1 (1st March 2023)

• Record Type: Journal Article
• Authors: Liu, Chunping; Liu, Yanjiao; Chen, Huiqi; Yang, Xiaofei; Lu, Chuanjian; Wang, Lei; Lu, Jiahong
• Is Part Of: Burns and trauma. Volume 11:Issue 1(2023)
• Publication Date: 2023-03-01
• Subjects: Autophagy -- Inflammation -- Myocardial injury; Burns and scalds -- Periodicals; Wounds and injuries -- Periodicals; 617.11
• DOI: 10.1093/burnst/tkac062
• Languages: English
• ISSNs: 2321-3876

Abstract

Abstract: Autophagy is a highly conserved bulk degradation mechanism that degrades damaged organelles, aged proteins and intracellular contents to maintain the homeostasis of the intracellular microenvironment. Activation of autophagy can be observed during myocardial injury, during which inflammatory responses are strongly triggered. Autophagy can inhibit the inflammatory response and regulate the inflammatory microenvironment by removing invading pathogens and damaged mitochondria. In addition, autophagy may enhance the clearance of apoptotic and necrotic cells to promote the repair of damaged tissue. In this paper, we briefly review the role of autophagy in different cell types in the inflammatory microenvironment of myocardial injury and discuss the molecular mechanism of autophagy in regulating the inflammatory response in a series of myocardial injury conditions, including myocardial ischemia, ischemia/reperfusion injury and sepsis cardiomyopathy.