Medical History, Lifestyle, Family History, and Occupational Risk Factors for Mantle Cell Lymphoma: The InterLymph Non-Hodgkin Lymphoma Subtypes Project. Issue 48 (30th August 2014)

• Record Type: Journal Article
• Authors: Smedby, Karin E.; Sampson, Joshua N.; Turner, Jennifer J.; Slager, Susan L.; Maynadié, Marc; Roman, Eve; Habermann, Thomas M.; Flowers, Christopher R.; Berndt, Sonja I.; Bracci, Paige M.; Hjalgrim, Henrik; Weisenburger, Dennis D.; Morton, Lindsay M.
• Is Part Of: Journal of the National Cancer Institute. Issue 48(2014)
• Page Start: 76
• Page End: 86
• Publication Date: 2014-08-30
• Subjects: Cancer -- Periodicals; Cancer -- Congresses; 616.994
• DOI: 10.1093/jncimonographs/lgu007
• Languages: English
• ISSNs: 1052-6773

Abstract

Abstract: Background: The etiology of mantle cell lymphoma (MCL), a distinctive subtype accounting for 2%–10% of all non-Hodgkin lymphoma, is not known. Methods: We investigated associations with self-reported medical history, lifestyle, family history, and occupational risk factors in a pooled analysis of 557 patients with MCL and 13766 controls from 13 case–control studies in Europe, North America, and Australia. Odds ratios (ORs) and 95% confidence intervals (CIs) associated with each exposure were examined using multivariate logistic regression models. Results: The median age of the MCL patients was 62 years and 76% were men. Risk of MCL was inversely associated with history of hay fever (OR = 0.63, 95% CI = 0.48 to 0.82), and the association was independent of other atopic diseases and allergies. A hematological malignancy among first-degree relatives was associated with a twofold increased risk of MCL (OR = 1.99, 95% CI = 1.39 to 2.84), which was stronger in men (OR = 2.21, 95% CI = 1.44 to 3.38) than women (OR = 1.61, 95% CI = 0.82 to 3.19). A modestly increased risk of MCL was also observed in association with ever having lived on a farm (OR = 1.40, 95% CI = 1.03 to 1.90). Unlike some other non-Hodgkin lymphoma subtypes, MCL risk was not statistically significantly associated with autoimmune disorders, tobacco smoking, alcohol intake, body mass index, or ultraviolet radiation. Conclusions: The novel observations of a possible role for atopy and allergy and farm life in risk of MCL, together with confirmatory evidence of a familial link, suggest a multifactorial etiology of immune-related environmental exposures and genetic susceptibility. These findings provide guidance for future research in MCL etiology.