Long-term study of indomethacin and alclofenac in treatment of rheumatoid arthritis. Issue 5961 (5th April 1975)

• Record Type: Journal Article
• Authors: Aylward, M; Parker, R J; Holly, F; Maddock, J; Davies, D B
• Is Part Of: BMJ. Volume 2:Issue 5961(1975)
• Page Start: 7
• Page End: 9
• Publication Date: 1975-04-05
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.2.5961.7
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : Indomethacin and alclofenac were compared for 13 months under double-blind conditions in 109 patients with active, classical, or definite rheumatoid arthritis at a relatively early stage of the disease. Both indomethacin and alclofenac were clearly effective: most patients either improved or remained as well controlled as on entry. Alclofenac proved the more effective drug, however, producing a significantly greater reduction in morning stiffness, articular index, and erythrocyte sedimentation rate, and only in the alclofenac-treated group did functional capacity improve and latex-agglutination titres diminish. Comprehensive laborabory tests showed no significant deviation from normal which could have been attributed to either drug.