Oestrogen/Progestogen Oral Contraception and Blood Clotting: A Long-term Follow-up. Issue 5788 (11th December 1971)

• Record Type: Journal Article
• Authors: Poller, L.; Thomson, Jean M.; Thomas, Wendy
• Is Part Of: BMJ. Volume 4:Issue 5788(1971)
• Page Start: 648
• Page End: 650
• Publication Date: 1971-12-11
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.4.5788.648
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : In a long-term study of women taking the combined oestrogen/progestogen oral contraceptives Ortho-Novin and Norinyl-1 the follow-up has been continued for three years and four years respectively. Acceleration of both "intrinsic" and "extrinsic" clotting tests and of specific factor VII and X assays, reported previously at the nine-month stage, persisted throughout the period of study. Acceleration of Chandler's tube platelet aggregation and hypercoagulable thrombelastographic patterns were recorded. There was, however, no evidence of a cumulative effect after the first nine months.