Predicting brain temperature in humans using bioheat models: Progress and outlook. Issue 6 (June 2023)

• Record Type: Journal Article
• Authors: Sung, Dongsuk; Rejimon, Abinand; Allen, Jason W; Fedorov, Andrei G; Fleischer, Candace C
• Is Part Of: Journal of cerebral blood flow & metabolism. Volume 43:Issue 6(2023)
• Page Start: 833
• Page End: 842
• Publication Date: 2023-06
• Subjects: Brain thermal model -- brain temperature -- bioheat equations -- therapeutic hypothermia -- thermal ablation; Cerebral circulation -- Periodicals; Brain -- Metabolism -- Periodicals; Brain -- Blood-vessels -- Periodicals; Cerebrovascular disease -- Periodicals; 612.824
• DOI: 10.1177/0271678X231162173
• Languages: English
• ISSNs: 0271-678X

Abstract

Brain temperature, regulated by the balance between blood circulation and metabolic heat generation, is an important parameter related to neural activity, cerebral hemodynamics, and neuroinflammation. A key challenge for integrating brain temperature into clinical practice is the lack of reliable and non-invasive brain thermometry. The recognized importance of brain temperature and thermoregulation in both health and disease, combined with limited availability of experimental methods, has motivated the development of computational thermal models using bioheat equations to predict brain temperature. In this mini-review, we describe progress and the current state-of-the-art in brain thermal modeling in humans and discuss potential avenues for clinical applications.