Childhood obesity: A review of current and future management options. (8th November 2021)

• Record Type: Journal Article
• Authors: Apperley, Louise J.; Blackburn, James; Erlandson‐Parry, Karen; Gait, Lucy; Laing, Peter; Senniappan, Senthil
• Is Part Of: Clinical endocrinology. Volume 96:Number 3(2022)
• Page Start: 288
• Page End: 301
• Publication Date: 2021-11-08
• Subjects: BMI -- childhood obesity -- lifestyle interventions -- paediatrics -- pharmacotherapy; Endocrinology -- Periodicals; 616.4005
• DOI: 10.1111/cen.14625
• Languages: English
• ISSNs: 0300-0664

Abstract

Abstract: Obesity is becoming increasingly prevalent in paediatric populations worldwide. In addition to increasing prevalence, the severity of obesity is also continuing to rise. Taken together, these findings demonstrate a worrying trend and highlight one of the most significant challenges to public health. Childhood obesity affects multiple organs in the body and is associated with both significant morbidity and ultimately premature mortality. The prevalence of complications associated with obesity, including dyslipidaemia, hypertension, fatty liver disease and psychosocial complications are becoming increasingly prevalent within the paediatric populations. Treatment guidelines currently focus on intervention with lifestyle and behavioural modifications, with pharmacotherapy and surgery reserved for patients who are refractory to such treatment. Research into adult obesity has established pharmacological novel therapies, which have been approved and established in clinical practice; however, the research and implementation of such therapies in paediatric populations have been lagging behind. Despite the relative lack of widespread research in comparison to the adult population, newer therapies are being trialled, which should allow a greater availability of treatment options for childhood obesity in the future. This review summarizes the current evidence for the management of obesity in terms of medical and surgical options. Both future therapeutic agents and those which cause weight loss but have an alternative indication are also included and discussed as part of the review. The review summarizes the most recent research for each intervention and demonstrates the potential efficacy and limitations of each treatment option.