Presence of Particles other than the Australia-SH Antigen in a Case of Chronic Active Hepatitis with Cirrhosis. Issue 5691 (31st January 1970)

• Record Type: Journal Article
• Authors: Zuckerman, A. J.; Taylor, Patricia E.
• Is Part Of: BMJ. Volume 1:Issue 5691(1970)
• Page Start: 262
• Page End: 264
• Publication Date: 1970-01-31
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.1.5691.262
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : Examination of serum specimens from a patient with chronic active hepatitis proved negative to the Australia-SH antigen by immunodiffusion and by complement fixation. Because the sera were anticomplementary they were examined with the electron microscope, and virus-like structures similar to members of the coronavirus group were identified. The possible significance of this finding in human serum and its relation to mouse hepatitis virus are discussed. A sample of the serum pool containing the MS-1 agent was found negative when examined by immunodiffusion, complement fixation, and electron microscopy. The possible lack of immunological identity between infectious and serum hepatitis is discussed.