Asymmetric distribution of enlarged perivascular spaces in centrum semiovale may be associated with epilepsy after acute ischemic stroke. (3rd January 2022)

• Record Type: Journal Article
• Authors: Yu, Nian; Sinclair, Benjamin; Posada, Lina Maria Garcia; Chen, Zhibin; Di, Qing; Lin, Xingjian; Kolbe, Scott; Hlauschek, Gernot; Kwan, Patrick; Law, Meng
• Is Part Of: CNS neuroscience & therapeutics. Volume 28:Number 3(2022)
• Page Start: 343
• Page End: 353
• Publication Date: 2022-01-03
• Subjects: asymmetric index -- centrum semiovale -- enlarged perivascular space -- epileptogenesis -- post‐stroke epilepsy; Neuropharmacology -- Periodicals; Central nervous system -- Diseases -- Effect of drugs on -- Periodicals; 612.8
• DOI: 10.1111/cns.13786
• Languages: English
• ISSNs: 1755-5930

Abstract

Abstract: Objective: To investigate the factors influencing enlarged perivascular space (EPVS) characteristics at the onset of acute ischemic stroke (AIS), and whether the PVS characteristics can predict later post‐stroke epilepsy (PSE). Methods: A total of 312 patients with AIS were identified, of whom 58/312 (18.6%) developed PSE. Twenty healthy participants were included as the control group. The number of PVS in the basal ganglia (BG), centrum semiovale (CS), and midbrain (MB) was manually calculated on T2 ‐weighted MRI. The scores and asymmetry index (AI) of EPVS in each region were compared among the enrolled participants. Other potential risk factors for PSE were also analyzed, including NIHSS at admission and stroke etiologies. Results: The EPVS scores were significantly higher in the bilateral BG and CS of AIS patients compared to those of the control group (both p < 0.01). No statistical differences in EPVS scores in BG, CS, and MB were obtained between the PSE group and the nonepilepsy AIS group (all p > 0.01). However, markedly different AI scores in CS were found between the PSE group and the nonepilepsy AIS group ( p = 0.004). Multivariable analysis showed that high asymmetry index of EPVS (AI≥0.2) in CS was an independent predictor for PSE (OR = 3.7, 95% confidence interval 1.5–9.1, p = 0.004). Conclusions: Asymmetric distribution of EPVS in CS may be an independent risk factor and a novel imaging biomarker for the development of PSE. Further studies to understand the mechanisms of this association and confirmation with larger patient populations are warranted. Abstract : Higher asymmetry index scores of EPVS in CS are found in post‐stroke epilepsy patients. An asymmetric distribution of EPVS in CS is an independent risk factor or a novel imaging biomarker for post‐stroke epilepsy.