Haemolysis complicating viral hepatitis in patients with glucose-6-phosphate dehydrogenase deficiency. Issue 5950 (18th January 1975)

• Record Type: Journal Article
• Authors: Chan, T K; Todd, D
• Is Part Of: BMJ. Volume 1:Issue 5950(1975)
• Page Start: 131
• Page End: 133
• Publication Date: 1975-01-18
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.1.5950.131
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : Out of 20 patients with viral hepatitis whose glucose-6-phosphate dehydrogenase (G-6-PD) levels were normal, 14 had clinical evidence of a mild to moderate degree of haemolysis but in all the patients studied the half life of chromium-51-labelled red cells was shortened. Out of 18 viral hepatitis patients deficient in G-6-PD 17 had clinical evidence of haemolysis, and in eight this was more severe than in the group with normal G-6-PD values. Massive intravascular haemolysis occurred in four, three of whom died. The massive haemolysis was attributed to the presence of additional drug-induced oxidative stress to the G-6-PD-deficient red cells.