Factor V Leiden Mutation–Related Chronic Skin Ulcers. (March 2013)

• Record Type: Journal Article
• Authors: Kayatas, Kadir; Cebeci, Filiz; Karatoprak, Cumali; Benzer, Muhammet; Demirtunç, Refik; Demirkesen, Cuyan
• Is Part Of: International journal of lower extremity wounds. Volume 12:Number 1(2013)
• Page Start: 35
• Page End: 38
• Publication Date: 2013-03
• Subjects: factor V Leiden mutation -- chronic skin ulcer -- anticoagulant treatment; Leg -- Wounds and injuries -- Periodicals; Wounds and injuries -- Prevention -- Periodicals; Leg -- Ulcers -- Periodicals; Wound healing -- Periodicals; 617.584
• DOI: 10.1177/1534734613479379
• Languages: English
• ISSNs: 1534-7346

Abstract

Chronic skin ulcers require extensive, systemic differential diagnosis; thus, they are difficult to diagnose and treat. Transient or persistent hypercoagulable states are among the rare causes of skin ulcers. Here, we present the case of a 27-year-old woman patient with recurrent, nonhealing skin ulcers of 8 years' duration, who had been treated unsuccessfully with various medications under different diagnoses at different clinics. On admission, a skin biopsy demonstrated occlusive vasculopathy, and the search for an inherited hypercoagulable state revealed a heterozygous factor V Leiden mutation. The patient was treated with anticoagulants and hyperbaric oxygen. On treatment, the skin lesions healed and did not recur.