A Chronic Leg Ulcer Presenting With Charcot–Marie–Tooth Disease and Type 2 Diabetes: A Case Report. (March 2013)

• Record Type: Journal Article
• Authors: Ren, Haitao; You, Chuangang; Han, Chunmao
• Is Part Of: International journal of lower extremity wounds. Volume 12:Number 1(2013)
• Page Start: 30
• Page End: 34
• Publication Date: 2013-03
• Subjects: Charcot–Marie–Tooth (CMT) disease -- diabetes -- ulcer; Leg -- Wounds and injuries -- Periodicals; Wounds and injuries -- Prevention -- Periodicals; Leg -- Ulcers -- Periodicals; Wound healing -- Periodicals; 617.584
• DOI: 10.1177/1534734613477660
• Languages: English
• ISSNs: 1534-7346

Abstract

Charcot–Marie–Tooth (CMT) disease is characterized by hereditary sensorimotor polyneuropathy with foot deformity, sensorineural hearing loss, moderate developmental delay, and gait disturbance. CMT presenting with type 2 diabetes and an ulcer has not been reported. This article reports a man who presented with the symptoms mentioned above and also with a leg ulcer and type 2 diabetes. He was diagnosed with CMT disease based on family history and genetic testing. A skin defect in the left leg had manifested for more than 1 year, and results of initial fasting plasma glucose revealed type 2 diabetes. The evolution of these manifestations, coupled with a slowly progressive weakness, numbness, muscular wasting, and sensory impairment, strongly suggested the co-occurrence of 3 different diseases in the same individual.