Fabrication of moxifloxacin HCl-loaded biodegradable chitosan nanoparticles for potential antibacterial and accelerated cutaneous wound healing efficacy. (2nd January 2022)

• Record Type: Journal Article
• Authors: Hameed, Misbah; Rasul, Akhtar; Latif, Sumera; Rasool, Maria; Abbas, Ghulam; Siddique, Muhammad Irfan; Waqas, Muhammad Khurram; Khan, Ikram Ullah; Yousaf, Abid Mehmood; Shah, Pervaiz Akhtar
• Is Part Of: Journal of microencapsulation. Volume 39:Number 1(2022)
• Page Start: 37
• Page End: 48
• Publication Date: 2022-01-02
• Subjects: Moxifloxacin HCl -- nanoparticles -- chitosan -- antibacterial -- wound healing; Microencapsulation -- Periodicals; Controlled release technology -- Periodicals; 615.19
• DOI: 10.1080/02652048.2021.2019332
• Languages: English
• ISSNs: 0265-2048

Abstract

Abstract: Aim: This work aims to formulate topical hybrid gel containing chitosan-coated moxifloxacin (MXF) HCl nanoparticles (NPs) with enhanced antibacterial and healing activity. Methods: MXF HCl NPs prepared by the ionic gelation method were loaded onto a hybrid chitosan carbomer gel. Size analysis of the prepared NPs was performed using SEM and Zeta-sizer. Further characterisation was done using Fourier transforms infra-red spectroscopy (FTIR), X-ray diffraction (XRD), and Thermogravimetric analysis (TGA). Prepared gel was evaluated for its in vitro drug release, biocompatibility, antibacterial activity, and stability studies under storage conditions. In-vivo wound healing was measured by observing percentage reduction in wound. Results: NPs have 359 ± 79 nm mean particle size, 31.01 mV zeta potential with 0.008 polydispersity index (PD1), 63.5% drug entrapment and 83 ± 3.5% drug release at pH 5.5. Hybrid chitosan carbomer gel showed good biocompatibility, antibacterial, in-vivo wound healing properties and stable properties. Conclusions: NP-loaded hybrid gel can be an effective treatment for acute and challenged topical wounds.