Clinical and magnetic resonance study of a case of subacute sclerosing panencephalitis treated with ketogenic diet. Issue 2 (23rd July 2021)

• Record Type: Journal Article
• Authors: Valente, Mariarosaria; Del Negro, Ilaria; Bagatto, Daniele; Garbo, Riccardo; Lettieri, Christian; Bernardini, Andrea; Nilo, Annacarmen; Peri, Maria Rosaria; Pecori, Davide; Gigli, Gian Luigi
• Is Part Of: BMJ neurology open. Volume 3:Issue 2(2021)
• Publication Date: 2021-07-23
• Subjects: clinical neurology -- infectious diseases -- MR; Neurology -- Periodicals; 616.8
• DOI: 10.1136/bmjno-2021-000176
• Languages: English
• ISSNs: 2632-6140

Abstract

Abstract : Background: Subacute sclerosing panencephalitis is a progressive neurodegenerative disorder caused by a latent and mutant measles virus which is extremely rare in developed countries. The lack of effective treatments leads to the research of other anti-inflammatory and neuroprotective treatments. Case: Here we present a case of a 17-year-old patient affected by subacute sclerosing panencephalitis who manifest a dramatic improvement in neurological and general clinical conditions, as well as an arrest in the progression of demyelinating process in the central nervous system, after the beginning of a high ratio ketogenic diet. Conclusions: Given its anti-inflammatory, antioxidant and metabolic effects, we believe that ketogenic diet utilisation could be a rational approach, can be considered a safe add-on therapy, carrying on with only a minimal risk of adverse effects or interactions.