T lymphocytes in kidney allograft recipients. Issue 6013 (3rd April 1976)

• Record Type: Journal Article
• Authors: Tursz, T; Fournier, C; Kreis, H; Crosnier, J; Bach, J F
• Is Part Of: BMJ. Volume 1:Issue 6013(1976)
• Page Start: 799
• Page End: 801
• Publication Date: 1976-04-03
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.1.6013.799
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : The spontaneous sheep erythrocyte (E) rosette test was used on 340 occasions to measure T cell levels in 28 renal allograft recipients. The E rosette counts were reduced by high-dose steroids but usually returned towards normal under maintenance treatment with azathioprine and low-dose prednisone. Unexpectedly, rejection crises were more often associated with a decrease in E rosettes before steroid treatment (12 cases) than with an increase in E rosettes (5 cases). Our results show the need for caution in using the E rosette test and more generally B and T cell markers for monitoring anti-graft immunity in renal allograft recipients.