A Timely Oral Option: Single‐Agent Vinorelbine in Desmoid Tumors. (2nd October 2020)

• Record Type: Journal Article
• Authors: Gennatas, Spyridon; Chamberlain, Florence; Smrke, Alannah; Stewart, James; Hayes, Andrew; Roden, Lorna; Messiou, Christina; Kowa, Jie‐Ying; Estival, Anna; Chauhan, Dharmisha; Thway, Khin; Fisher, Cyril; van der Graaf, Winette T. A.; Jones, Robin L.; Benson, Charlotte
• Is Part Of: Oncologist. Volume 25:Number 12(2020)
• Page Start: e2013
• Page End: e2016
• Publication Date: 2020-10-02
• Subjects: Oncology -- Periodicals; Tumors -- Periodicals; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Oncology; Tumors; Neoplasms; Electronic journals; Periodicals; Periodicals; 616.994
• DOI: 10.1002/ONCO.13516
• Languages: English
• ISSNs: 1083-7159

Abstract

Abstract: Introduction: Desmoid tumors (DT) are rare collagen‐forming tumors that can exhibit locally aggressive patterns of behavior. The aim of this study was to evaluate the efficacy and safety of treatment of DT with single‐agent oral vinorelbine. Materials and Methods: A retrospective review of patients treated with vinorelbine 90 mg orally on days 1, 8, and 15 of a 28‐day cycle from January 2004 to July 2019 was performed. Response was assessed using RECIST version 1.1. Descriptive statistics were employed. Results: A total of 29 patients were included. Response rate was 20.7% (6/29), and clinical benefit rate (response by RECIST 1.1 and/or clinical symptom improvement) was 65.5% (19/29). No patient experienced grade 3 or above toxicity. Common toxicities were grade 1–2 nausea (14/26, 48.3%), fatigue (9/26, 31.0%), and diarrhea (4/26, 13.8%). Conclusion: Single‐agent oral vinorelbine is an effective, safe, and well‐tolerated treatment for DT. It represents a new oral alternative for management of DT. Abstract : Methotrexate combined with vinorelbine or vinblastine have been used to treat desmoid tumors combined with either vinorelbine or vinblastine has been effectively used to treat patients with desmoid tumors but requires intravenous treatment. An oral regimen that limits hospital visits would be ideal. This article evaluates the efficacy and safety of single‐agent oral vinorelbine and reports promising results.