The effects of progesterone on immune cellular function at the maternal-fetal interface and in maternal circulation. Issue 229 (May 2023)

• Record Type: Journal Article
• Authors: Motomura, Kenichiro; Miller, Derek; Galaz, Jose; Liu, Tzu Ning; Romero, Roberto; Gomez-Lopez, Nardhy
• Is Part Of: Journal of steroid biochemistry and molecular biology. Issue 229(2022)
• Publication Date: 2023-05
• Subjects: 17OHP-C 17-alpha-hydroxyprogesterone caproate -- CSF-1 colony stimulating factor-1 -- DBA dolichos biflorus agglutinin -- DC dendritic cell -- dpc days post coitum -- Gal-1 Galectin-1 -- GR glucocorticoid receptor -- hCG human chorionic gonadotropin -- HMGB1 nuclear protein high-mobility group box-1 -- IDO indoleamine-2, 3-dioxygenase -- IL interleukin -- IMC immature myeloid cell -- iTreg induced regulatory T cell -- LDL low-density lipoprotein -- LH luteinizing hormone -- LPS lipopolysaccharide -- MCP-1 macrophage chemoattractant protein-1 -- MPA medroxyprogesterone acetate -- mPR membrane progesterone receptor -- NET neutrophil extracellular trap -- niT cell neutrophil-induced T cell -- NK cell natural killer cell -- nPR nuclear progesterone receptor -- P4 progesterone -- PAMP pathogen-associated molecular pattern -- PAPP-A pregnancy associated plasma protein A -- PBMC peripheral blood mononuclear cell -- PIBF progesterone-induced blocking factor -- PGRMC progesterone receptor membrane component -- pMSC placental mesenchymal stem cell -- PR progesterone receptor -- RANTES Regulated upon Activation, Normal T Cell Expressed and Presumably Secreted -- RUPP reduced uterine perfusion pressure -- TCR T-cell receptor -- Th T helper cell -- Treg regulatory T cell -- VIP vasoactive intestinal peptide; Decidua -- Dendritic cell -- Macrophage -- Neutrophil -- NK cell -- Pregnancy -- T cell; Steroid hormones -- Periodicals; Biochemistry -- Periodicals; Hormones -- Periodicals; Molecular Biology -- Periodicals; Hormones stéroïdes -- Périodiques; Steroid hormones; Periodicals; 572.579
• DOI: 10.1016/j.jsbmb.2023.106254
• Languages: English
• ISSNs: 0960-0760

Abstract

Abstract: Progesterone is a sex steroid hormone that plays a critical role in the establishment and maintenance of pregnancy. This hormone drives numerous maternal physiological adaptations to ensure the continuation of pregnancy and to facilitate fetal growth, including broad and potent modulation of the maternal immune system to promote maternal-fetal tolerance. In this brief review, we provide an overview of the immunomodulatory functions of progesterone in the decidua, placenta, myometrium, and maternal circulation during pregnancy. Specifically, we summarize current evidence of the regulated functions of innate and adaptive immune cells induced by progesterone and its downstream effector molecules in these compartments, including observations in human pregnancy and in animal models. Our review highlights the gaps in knowledge of interactions between progesterone and maternal cellular immunity that may direct future research. Highlights: Progesterone has specific effects on local and systemic cellular immunity. Progesterone promotes maternal-fetal tolerance by expanding regulatory T cells. Progesterone regulates the infiltration and activity of inflammatory immune cells.