Insufficient sleep may alter cortical excitability near the migraine attack: A blinded TMS crossover study. (March 2023)

• Record Type: Journal Article
• Authors: Mykland, Martin Syvertsen; Uglem, Martin; Stovner, Lars Jacob; Brenner, Eiliv; Snoen, Mari Storli; Gravdahl, Gøril Bruvik; Sand, Trond; Omland, Petter Moe
• Is Part Of: Cephalalgia. Volume 43:Number 3(2023)
• Publication Date: 2023-03
• Subjects: TMS -- GABA -- cholinergic -- preictal -- postictal -- hypothalamus; Headache -- Periodicals; 616.8491
• DOI: 10.1177/03331024221148391
• Languages: English
• ISSNs: 0333-1024

Abstract

Background: Migraine is a brain disorder with a multifaceted and unexplained association to sleep. Brain excitability likely changes periodically throughout the migraine cycle. In this study we examine the effect of insufficient sleep on neuronal excitability during the course of the migraine cycle. Methods: We examined 54 migraine patients after two nights of eight-hour habitual sleep and two nights of four-hour restricted sleep in a randomised, blinded crossover study. We performed transcranial magnetic stimulation and measured cortical silent period, short- and long-interval intracortical inhibition, intracortical facilitation and short-latency afferent inhibition. We analysed how responses changed before and after attacks with linear mixed models. Results: Short- interval intracortical inhibition was more reduced after sleep restriction compared to habitual sleep the shorter the time that had elapsed since the attack ( p = 0.041), and specifically in the postictal phase ( p = 0.013). Long-interval intracortical inhibition was more increased after sleep restriction with time closer before the attack ( p = 0.006), and specifically in the preictal phase ( p = 0.034). Short-latency afferent inhibition was more decreased after sleep restriction with time closer to the start of the attack ( p = 0.026). Conclusion: Insufficient sleep in the period leading up to a migraine attack may cause dysfunction in cortical GABAergic inhibition. The results also suggest that migraine patients may have increased need for sufficient sleep during a migraine attack to maintain normal neurological function after the attack.