The incremental shuttle walk test predicts mortality in non‐group 1 pulmonary hypertension: results from the ASPIRE Registry. (1st May 2019)

• Record Type: Journal Article
• Authors: Billings, Catherine G.; Lewis, Robert; Hurdman, Judith A.; Condliffe, Robin; Elliot, Charlie A.; Thompson, A.A. Roger; Smith, Ian A.; Austin, Matthew; Armstrong, Iain J.; Hamilton, Neil; Charalampopoulos, Athanasios; Sabroe, Ian; Swift, Andrew J.; Rothman, Alexander M.; Wild, Jim M.; Lawrie, Allan; Waterhouse, Judith C.; Kiely, David G.
• Is Part Of: Pulmonary circulation. Volume 9:Number 2(2019)
• Page Start: 1
• Page End: 9
• Publication Date: 2019-05-01
• Subjects: exercise testing -- disease severity -- prognosis; Pulmonary circulation -- Periodicals; Pulmonary circulation; Electronic journals -- Sciences; Periodicals; 616.24005
• DOI: 10.1177/2045894019848649
• Languages: English
• ISSNs: 2045-8932

Abstract

Abstract : Pulmonary hypertension (PH) is classified into five groups based on disease etiology but there is only limited information on the prognostic value of exercise testing in non‐group 1 PH. In group 1 PH, the incremental shuttle walking test (ISWT) distance has been shown to correlate with pulmonary hemodynamics and predict survival without a ceiling effect. This study assessed the ISWT in non‐group 1 PH. Data were retrieved from the ASPIRE Registry (Assessing the Spectrum of Pulmonary hypertension Identified at a REferral centre) for consecutive patients diagnosed with PH. Patients were required to have been systematically assessed as group 2–5 PH and to have a baseline ISWT within three months of cardiac catheterization. Patients were stratified according to incremental shuttle walk test distance (ISWD) and ISWT distance percent predicted (ISWD%pred). A total of 479 patients with non‐group 1 PH were identified. ISWD and ISWD%pred correlated significantly with symptoms and hemodynamic severity. ISWD and ISWD%pred predicted survival with no ceiling effect. The test was prognostic in groups 2, 3, and 4. ISWD and ISWD%pred and change in ISWD and ISWD%pred at one year were all significant predictors of outcome. In patients with non‐group 1 PH the ISWT is a simple non‐invasive test that is easy to perform, is predictive of survival at baseline and follow‐up, reflects change, and can be used in the assessment of PH of any etiology.