Case series: expanding diagnostic markers in postorgasmic illness syndrome. Issue 2 (2nd March 2023)

• Record Type: Journal Article
• Authors: Rosetti, Leah; Kanani, Amin; Witherspoon, Luke; Flannigan, Ryan; Elliott, Stacy
• Is Part Of: Sexual medicine. Volume 11:Issue 2(2023)
• Publication Date: 2023-03-02
• Subjects: Postorgasmic illness syndrome -- POIS -- ejaculation -- case series; Sexual disorders -- Periodicals; Sexual health -- Periodicals; 616.69005
• DOI: 10.1093/sexmed/qfac021
• Languages: English
• ISSNs: 2050-1161

Abstract

Abstract: Introduction: Postorgasmic illness syndrome (POIS) is a rare condition in which individuals develop generalized and flu-like symptoms after ejaculation. Several mechanisms and treatments for this disorder have been proposed but many questions remain. Aims: We sought to present a summary of literature to date and highlight common symptoms, associated features, comorbidities, and laboratory findings in a clinical sample of patients with POIS. Methods: We conducted a retrospective chart review of 6 patients with POIS in our clinic and presented compiled results. Results: We identified newly described non–flu-like presentations, onset of symptoms with high states of arousal without ejaculation, and presence of psychiatric comorbidity in a majority of patients. We did not identify a postorgasm allergic response with bloodwork available. Conclusion: POIS remains a poorly understood condition that likely comprises a number of different clinical entities. Further research on a larger clinical sample is necessary to better characterize POIS and understand its biological and psychological basis.