Metaumbrella: the first comprehensive suite to perform data analysis in umbrella reviews with stratification of the evidence. Issue 1 (15th February 2023)

• Record Type: Journal Article
• Authors: Gosling, Corentin J; Solanes, Aleix; Fusar-Poli, Paolo; Radua, Joaquim
• Is Part Of: BMJ mental health. Volume 26:Issue 1(2023)
• Publication Date: 2023-02-15
• Subjects: PSYCHIATRY -- Child & adolescent psychiatry -- Adult psychiatry; 616.89
• DOI: 10.1136/bmjment-2022-300534
• Languages: English
• ISSNs: 2755-9734

Abstract

Abstract : Objective: Umbrella reviews are a new form of literature review that summarises the strength and/or quality of the evidence from all systematic reviews and meta-analyses conducted on a broad topic. This type of review thus provides an exhaustive examination of a vast body of information, providing the highest synthesis of knowledge. A critical strength of umbrella reviews is recalculating the meta-analytic estimates within a uniform framework to allow a consistent evidence stratification. To our best knowledge, there is no comprehensive package or software to conduct umbrella reviews. Methods: The R package metaumbrella accomplishes this aim by building on three core functions that (1) automatically perform all required calculations in an umbrella review (including but not limited to pairwise meta-analyses), (2) stratify evidence according to various classification criteria and (3) generate a visual representation of the results. In addition, this package allows flexible inputs for each review or meta-analysis analysed (eg, means plus SD, or effect size estimate and CI) and customisation (eg, stratification criteria following Ioannidis, algorithmic GRADE or personalised classification). Results: The R package metaumbrella thus provides the first comprehensive range of facilities to perform umbrella reviews with stratification of the evidence. Conclusion: To facilitate the use of this package, even for researchers unfamiliar with R, we also provide a JAMOVI module and an open-access, browser-based graphical interface that allow use of the core functions of the package with a few mouse clicks.