Asymmetric Henry Reaction of Trifluoromethyl Enones with Nitromethane Using a N, N‐Dibenzyl Diaminomethylenemalononitrile Organocatalyst. Issue 4 (12th January 2022)

• Record Type: Journal Article
• Authors: Kawada, Masahiro; Tsuyusaki, Ryo; Nakashima, Kosuke; Yamada, Misaki; Kozakai, Akihiro; Matsushima, Yasuyuki; Hirashima, Shin‐ichi; Miura, Tsuyoshi
• Is Part Of: Chemistry, an Asian journal. Volume 17:Issue 4(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-01-12
• Subjects: asymmetric reaction -- Henry reaction -- nitromethane -- organocatalyst -- trifluoromethyl enone; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/asia.202101299
• Languages: English
• ISSNs: 1861-4728

Abstract

Abstract: A novel N, N ‐dibenzyl diaminomethylenemalononitrile organocatalyst efficiently promoted asymmetric Henry reactions of trifluoromethyl enones with nitromethane, affording corresponding highly functionalized products in high yields with excellent enantioselectivities (up to 90% ee ). This study is the first to report the successful example of the asymmetric 1, 2‐additions of nitromethane to trifluoromethyl enones. Abstract : A novel N, N ‐dibenzyl diaminomethylenemalononitrile organocatalyst efficiently promotes asymmetric Henry reactions of trifluoromethyl enones with nitromethane, affording the corresponding highly functionalized products in high yields with excellent enantioselectivities (up to 90% ee ).