Rh-Catalyzed diastereoselective addition of arylboronic acids to α-keto N-tert-butanesulfinyl aldimines: synthesis of α-amino ketones. Issue 4 (12th January 2022)

• Record Type: Journal Article
• Authors: Wang, Cece; Zhou, Lu; Qiu, Jian; Yang, Kai; Song, Qiuling
• Is Part Of: Organic chemistry frontiers. Volume 9:Issue 4(2022)
• Page Start: 1016
• Page End: 1022
• Publication Date: 2022-01-12
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d1qo01721g
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : Herein we present a diastereoselective addition of arylboronic acids to α-keto N-tert -butanesulfinyl aldimines catalyzed by a Rh(i ) catalyst. Abstract : Herein we present a diastereoselective addition of arylboronic acids to α-keto N-tert -butanesulfinyl aldimines catalyzed by a Rh(i ) catalyst. This reaction provides a practical method to obtain valuable chiral α-amino ketones with excellent diastereoselectivity, featuring operational simplicity, mild reaction conditions and a broad substrate scope.