Genetic variants affecting chemical mediated skin immunotoxicity. (17th February 2022)

• Record Type: Journal Article
• Authors: Rodrigues de Souza, Isisdoris; Savio de Araujo-Souza, Patrícia; Morais Leme, Daniela
• Is Part Of: Journal of toxicology and environmental health. Volume 25:Number 2(2022)
• Page Start: 43
• Page End: 95
• Publication Date: 2022-02-17
• Subjects: Inter-individual variability -- polymorphisms -- atopic dermatitis susceptibility -- skin immune diseases -- cytokine genes; Toxicology -- Periodicals; Environmental toxicology -- Periodicals; Environmental health -- Periodicals; 615.90205
• DOI: 10.1080/10937404.2021.2013372
• Languages: English
• ISSNs: 1093-7404

Abstract

ABSTRACT: The skin is an immune-competent organ and this function may be impaired by exposure to chemicals, which may ultimately result in immune-mediated dermal disorders. Interindividual variability to chemical-induced skin immune reactions is associated with intrinsic individual characteristics and their genomes. In the last 30–40 years, several genes influencing susceptibility to skin immune reactions were identified. The aim of this review is to provide information regarding common genetic variations affecting skin immunotoxicity. The polymorphisms selected for this review are related to xenobiotic-metabolizing enzymes ( CYPA1 and CYPB1 genes), antioxidant defense ( GSTM1, GSTT1, and GSTP1 genes), aryl hydrocarbon receptor signaling pathway ( AHR and ARNT genes), skin barrier function transepidermal water loss ( FLG, CASP14, and SPINK5 genes), inflammation ( TNF, IL10, IL6, IL18, IL31, and TSLP genes), major histocompatibility complex (MHC) and neuroendocrine system peptides ( CALCA, TRPV1, ACE genes). These genes present variants associated with skin immune responses and diseases, as well as variants associated with protecting skin immune homeostasis following chemical exposure. The molecular and association studies focusing on these genetic variants may elucidate their functional consequences and contribution in the susceptibility to skin immunotoxicity. Providing information on how genetic variations affect the skin immune system may reduce uncertainties in estimating chemical hazards/risks for human health in the future.