Adolescent development of inhibitory control and substance use vulnerability: A longitudinal neuroimaging study. (April 2020)

• Record Type: Journal Article
• Authors: Quach, Alina; Tervo-Clemmens, Brenden; Foran, William; Calabro, Finnegan J.; Chung, Tammy; Clark, Duncan B.; Luna, Beatriz
• Is Part Of: Developmental cognitive neuroscience. Volume 42(2020)
• Publication Date: 2020-04
• Subjects: Adolescence -- Substance use risk -- Externalizing psychopathology -- Inhibitory control -- fMRI -- Longitudinal; Cognitive neuroscience -- Periodicals; Developmental neurobiology -- Periodicals; Neuropsychology -- Periodicals; Neuropsychiatry -- Periodicals; 612.8233
• DOI: 10.1016/j.dcn.2020.100771
• Languages: English
• ISSNs: 1878-9293

Abstract

Highlights: Characterized inhibitory control development in adolescents at-risk for substance use. Externalizing psychopathology is associated with lower antisaccade accuracy and shorter latencies in early adolescence. Externalizing-associated inhibitory control performance differences normalize by late adolescence. Externalizing psychopathology is associated with prefrontal hypo-activation across development. Externalizing psychopathology moderates age-related increases in posterior parietal cortex activity. Abstract: Previous research indicates that risk for substance use is associated with poor inhibitory control. However, it remains unclear whether at-risk youth follow divergent patterns of inhibitory control development. As part of the longitudinal National Consortium on Adolescent Neurodevelopment and Alcohol study, participants (N = 113, baseline age: 12–21) completed a rewarded antisaccade task during fMRI, with up to three time points. We examined whether substance use risk factors, including psychopathology (externalizing, internalizing) and family history of substance use disorder, were associated with developmental differences in inhibitory control performance and BOLD activation. Among the examined substance use risk factors, only externalizing psychopathology exhibited developmental differences in inhibitory control performance, where higher scores were associated with lower correct response rates (p = .013) and shorter latencies (p < .001) in early adolescence that normalized by late adolescence. Neuroimaging results revealed higher externalizing scores were associated with developmentally-stable hypo-activation in the left middle frontal gyrus (p < .05 corrected), but divergent developmental patterns of posterior parietal cortex activation (p < .05 corrected). These findings suggest that early adolescence may be a unique period of substance use vulnerability via cognitive and phenotypic disinhibition.