The clock is ticking: the impact of ageing on T cell metabolism. Issue 11 (18th November 2019)

• Record Type: Journal Article
• Authors: Quinn, Kylie M; Palchaudhuri, Riya; Palmer, Clovis S; La Gruta, Nicole L
• Is Part Of: Clinical & translational immunology. Volume 8:Issue 11(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-11-18
• Subjects: ageing -- cell signalling -- immunosenescence -- metabolism -- T cell; Immunologic diseases -- Periodicals; Immunology -- Periodicals; Clinical medicine -- Periodicals; Immune System Diseases -- therapy; Immunotherapy; Immunologic Factors -- therapeutic use; Translational Medical Research; Molecular Targeted Therapy; Clinical medicine; Immunologic diseases; Immunology; Periodicals; Periodicals; Fulltext; Internet Resources; Periodicals; 616.079
• DOI: 10.1002/cti2.1091
• Languages: English
• ISSNs: 2050-0068

Abstract

Abstract: It is now clear that access to specific metabolic programmes controls the survival and function of various immune cell populations, including T cells. Efficient naïve and memory T cell homoeostasis requires the use of specific metabolic pathways and differentiation requires rapid and dramatic metabolic remodelling. While we are beginning to appreciate the crucial role of metabolic programming during normal T cell physiology, many of the potential impacts of ageing on metabolic homoeostasis and remodelling in T cells remain unexplored. This review will outline our current understanding of T cell metabolism and explore age‐related metabolic changes that are postulated or have been demonstrated to impact T cell function. Abstract : Specific metabolic programmes control the survival and function of T cells. As we age, T cell responses can become highly dysfunctional, but the impact of ageing on the T cell metabolism remains to be fully understood. This review summarises our current understanding and explores age‐related metabolic changes that are postulated or have been demonstrated to impact T cell function.