Access to enantioenriched molecules with diverse fluorinated tetrasubstituted stereocenters using hydroxy as a kinetic resolution auxiliary group. Issue 4 (14th January 2022)

• Record Type: Journal Article
• Authors: Zehra, Syeda Tazeen; Lan, Shouang; Zhang, Hao; Liu, Jinggong; Yang, Shuang; Fang, Xinqiang
• Is Part Of: Organic chemistry frontiers. Volume 9:Issue 4(2022)
• Page Start: 1040
• Page End: 1047
• Publication Date: 2022-01-14
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d1qo01493e
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : We describe in this paper that using secondary OH as the kinetic resolution auxiliary group, a series of previously unavailable fluorinated fully-substituted carbon molecules can be obtained with excellent level of enantioselectivities. Abstract : Developing a general method affording optically pure fully substituted carbon molecules bearing various fluorinated groups is highly important but very challenging. Here we show that using secondary OH as a kinetic resolution auxiliary group, a series of previously unavailable fluorinated fully substituted carbon molecules can be obtained with excellent enantioselectivities, thus providing an alternative complementary method that provides solutions to the limitations confronted by the known methods.