Cu(ii)-Catalyzed C2-site functionalization of p-aminophenols: an approach for selective cross-dehydrogenative aminations. Issue 4 (12th January 2022)

• Record Type: Journal Article
• Authors: Zhao, Xin; Yang, Fang; Wang, Lin-Lin; Guo, Jing; Xu, Yu-Qin; Chen, Zi-Sheng; Ji, Kegong
• Is Part Of: Organic chemistry frontiers. Volume 9:Issue 4(2022)
• Page Start: 1010
• Page End: 1015
• Publication Date: 2022-01-12
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d1qo01675j
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : Site selective cross dehydrogenative aminations from precursors without preactivated C–H and N–H bonds have been challenging. Abstract : Site selective cross dehydrogenative aminations from precursors without preactivated C–H and N–H bonds have been challenging. Herein, a copper-catalyzed C2-site selective amination of p -aminophenol derivatives with arylamines has been developed. This approach precludes both partners from prefunctionalization and yields single site selective aminated products. This reaction proceeds smoothly with air as a terminal oxidant to produce the corresponding C2-site functional aminophenol derivatives in moderate to good yields.