Implication of chemo‐resistant memory T cells for immune surveillance in patients with sarcoma receiving chemotherapy. Issue 9 (7th August 2017)

• Record Type: Journal Article
• Authors: Shibayama, Yuji; Tsukahara, Tomohide; Emori, Makoto; Murata, Kenji; Mizushima, Emi; Hirohashi, Yoshihiko; Kanaseki, Takayuki; Nakatsugawa, Munehide; Kubo, Terufumi; Yamashita, Toshihiko; Sato, Noriyuki; Torigoe, Toshihiko
• Is Part Of: Cancer science. Volume 108:Issue 9(2017)
• Page Start: 1739
• Page End: 1745
• Publication Date: 2017-08-07
• Subjects: Chemotherapy -- peripheral blood -- sarcoma -- stem cell memory -- young memory; Cancer -- Periodicals; Neoplasms -- Periodicals; Research -- Periodicals; Electronic journals; 616.994005
• DOI: 10.1111/cas.13319
• Languages: English
• ISSNs: 1347-9032

Abstract

Abstract : Chemotherapy has improved the prognosis of patients with sarcomas. However, it may suppress anti‐tumor immunity. Recently, we reported a novel CD8 + memory T cell population with a chemo‐resistance property, "young memory" T (TYM ) cells. In this study, we investigated the proportion and function of TYM cells in peripheral blood of healthy donors and sarcoma patients who received chemotherapy and those who did not. The proportion of TYM cells was significantly decreased in patients compared with that in healthy donors. In healthy donors, anti‐EBV CTLs were induced using mixed lymphocyte peptide culture, from not only TYM cells but also TCM and TEM cells. No CTLs directed to tumor‐associated antigens were induced. In sarcoma patients who did not receive chemotherapy, in addition to anti‐EBV CTLs, CTLs directed to the tumor‐associated antigen PBF were induced from TYM, TCM and TEM cells. In sarcoma patients who received chemotherapy, EBV‐specific CTLs were induced from TYM cells but were hardly induced from TEM cells. Interestingly, CTLs directed to the anti‐tumor‐associated antigen PBF were induced from TYM cells but not from the TCM and TEM cells in sarcoma patients who received chemotherapy. The findings suggest that TYM cells are resistant to chemotherapy and can firstly recover from the nadir. TYM cells might be important for immunological memory, especially in sarcoma patients receiving chemotherapy. Abstract : We investigated the proportion and function of a novel CD8+ memory T cells with a chemo‐resistance property, "young memory" T cells in healthy donors and sarcoma patients. CTLs directed to anti‐viral and tumor‐associated antigens were induced from TYM cells but not from the other T cell subsets in sarcoma patients who received high‐dose chemotherapy. The findings suggest that TYM cells might be important for immunological memory especially in sarcoma patients receiving chemotherapy.