Determination of IC50 values of anticancer drugs on cells by D2O – single cell Raman spectroscopy. Issue 14 (26th January 2022)
- Record Type:
- Journal Article
- Title:
- Determination of IC50 values of anticancer drugs on cells by D2O – single cell Raman spectroscopy. Issue 14 (26th January 2022)
- Main Title:
- Determination of IC50 values of anticancer drugs on cells by D2O – single cell Raman spectroscopy
- Authors:
- Lv, Wanxue
Fu, Boqiang
Li, Manli
Kang, Yu
Bai, Shouli
Lu, Chao - Abstract:
- Abstract : A simple, sensitive and repeatable D2 O-single cell Raman spectroscopy method was established to quantify the IC50 values of anticancer drugs by detecting C–D/(C–D + C–H) Raman peak area ratios after H and D exchange occurs in cell metabolism. Abstract : A simple, sensitive and repeatable D2 O-single cell Raman spectroscopy method is developed to quantify the inhibitory activity of anticancer drugs on cancer cell metabolism. The IC50 values obtained from A549 cells incubated with cisplatin and taxol are comparable with results of CCK-8 and ATP luminescent cell viability assays.
- Is Part Of:
- Chemical communications. Volume 58:Issue 14(2022)
- Journal:
- Chemical communications
- Issue:
- Volume 58:Issue 14(2022)
- Issue Display:
- Volume 58, Issue 14 (2022)
- Year:
- 2022
- Volume:
- 58
- Issue:
- 14
- Issue Sort Value:
- 2022-0058-0014-0000
- Page Start:
- 2355
- Page End:
- 2358
- Publication Date:
- 2022-01-26
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/d1cc06857a ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 26465.xml